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An alternative explanation is that differences in genetic backgrounds might account for these discrepancies since Pla and collaborators showed that elimination of Htt specifically in cortical and hippocampal neurons in the adult Hdh flox flox mouse leads to behavioral abnormalities, altered BDNF signaling, decreased survival and abnormal dendritic arborization of hippocampal newborn neurons already 6 months after Htt elimination 44 buy priligy 60 mg
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